Senior Statistician

Introduction to role:

Are you ready to turn complex data into decisions that bring new cancer treatments to patients sooner? As a Senior Statistician, you will shape pivotal study designs and interpret results that guide high‑stakes development choices across a fast-moving portfolio.

You will join a team that thrives on scientific curiosity, bold thinking and meticulous execution. Working alongside clinicians, translational scientists and regulatory experts, you will lead statistical strategy from early design through submission, using modern methods and simulation to improve trial efficiency and patient impact. Can you see yourself driving evidence that changes clinical practice while mentoring others to raise the statistical bar.

• Study Design Leadership: Lead the statistical strategy for clinical studies and programs, defining endpoints, estimates, and analysis plans that improve decision clarity and patient relevance.
• Regulatory Strategy Support: Shape and defend the statistical components of submissions; anticipate and address agency questions with clear, data-driven rationale.
• Data Synthesis for Decisions: Integrate internal and external evidence to inform design choices, sample sizes, and go/no‑go recommendations across indications.
• Modelling and Simulation: Apply simulation and quantitative methods to stress-test designs, optimize operating characteristics, and reduce cycle time without compromising quality.
• Technical Ownership: Serve as the technical owner for assigned studies or assets, ensuring methods, code, and processes are robust, reproducible, and aligned to standards.
• Methodology Innovation: Identify methodological gaps and introduce practical solutions—adaptive designs, Bayesian methods, missing data strategies—that improve clinical development.
• Delivery and Communication: Complete agreed deliverables on time; communicate complex results simply, enabling cross‑functional teams and leaders to act with confidence.
• Quality and Process Improvement: Develop and share procedures, tools and templates that lift quality, efficiency and consistency across the function; mentor peers in procedures.
• External Engagement: Contribute to publications and cross‑industry collaborations that advance statistical science and enhance the credibility of our evidence.

• Provides statistical expertise to support the design and interpretation of clinical studies, regulatory submissions and programmes of studies.
• Analyses internal and external information to inform design decisions
• Acts as a technical owner within Biostatistics with a deep understanding of processes and equipment employed.
• Provides support to the regulatory submissions including specification of overview documents and response to regulatory questions
• Keeps own knowledge of procedures and new relevant developments up to date.
• Finds opportunities for the application of modelling and simulation to improve study design.
• Finds opportunities to improve the methodology and provide practical solutions for clinical development.
• Delivers tasks as agreed and presents results.
• Identifies and applies statistical methodology to improve the process and provide practical solutions for research/production activities.
• Contributes to the development, sharing and statistical support of new procedures, tools or techniques to improve quality, efficiency and effectiveness of own area.

• Advanced degree in Statistics, Biostatistics or related quantitative field (PhD preferred)
• Proven experience designing and analyzing clinical trials in oncology or another complex therapeutic area
• Proficiency with SAS and R; experience with reproducible workflows and version control
• Hands-on experience with simulation frameworks for design evaluation and operating characteristics
• Familiarity with adaptive, Bayesian, or model‑based designs and estimand frameworks
• Direct interaction with global health authorities; contribution to high‑quality submission dossiers
• Strong record of scientific communication, including publications or conference presentations
• Ability to influence cross‑functional stakeholders and mentor junior statisticians.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Here, statisticians help transform promising science into medicines that change how cancer is treated. You will work at the intersection of cutting‑edge biology and technology, partnering with diverse experts who adapt quickly and publish in leading journals. Our track record includes multiple new oncology medicines over the past decade and sustained multi‑billion‑dollar investment in research, giving you the resources and scope to try new methods and see them realized in global programs. We champion curiosity and courage, bring unexpected teams together to solve hard problems, and value kindness alongside ambition—so your impact is felt by patients and teammates alike.

If you are ready to lead designs, sharpen decisions and accelerate breakthroughs for patients, step into this role and help write the next chapter in cancer medicine!

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.